When it comes to specific types and configurations of engines, the inline-six is one of the most long-lasting and reliable cylinder configurations to have ever been introduced. Some of the world’s most famously reliable engines were inline-six jobs, like the Ford 300 CID (4.9L) straight-six and the AMC/Jeep 4.0-liter. You can also make a strong argument for the Toyota 2JZ, too, as it’s well-known for its long-lasting nature and its ability to take quite a lot of abuse.